A skull is one of the items to obtain in Agony. They are mostly found in the Spider's Lair.


Most of Hell uses skulls as keys or offerings to access one place or something more beneficial.

In the Agony Mode, skulls function as a form of switch used to access each start of every round.

Forbidden FruitHeartInfantSkullStatuette
Garments of Adam
Crown of AdamNecklace of AdamRags of AdamArmlets of AdamSandals of Adam
Statue Parts
HeadLeft ArmLeft LegRight ArmRight Leg

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